Key Publications

Kato, T. et al. J Clin Invest. 2019;129(6):2542–2554 (2019).  Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation.

Sengupta, S., et al. Scientific Reports. Volume 9, Article Number: 4107 (2019). Discovery of NV-5138, the first selective Brain mTORC1 activator.

Mahoney SJ, et al. Nat Commun. 2018 Feb 7;9(1):548 A small molecule inhibitor of Rheb selectively targets mTORC1 signaling.

Shen, K., et al. Nature in press (2018). Architecture of the human GATOR1 and GATOR1–Rag GTPases complexes.

Scientific Poster: Sestrin2 modulator NV-5138, shows ketamine-like rapid antidepressant effects via direct activation of mTORC1 signaling

Gu, X., et al. Science 358:813:818 (2017). SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway.

Sabatini, D.M. Proc Natl Acad Sci USA. 2017 Oct 25. pii: 201716173. doi: 10.1073/pnas.1716173114. Twenty-five years of mTOR: Uncovering the link from nutrients to growth.

Wyant, G.A.., et al. Cell 171:642-654 (2017). mTORC1 Activator SLC38A9 Is Required to Efflux Essential Amino Acids from Lysosomes and Use Protein as a Nutrient.

Saxton, R.A. and Sabatini, D.M. Cell 169:361-371 (2017). mTOR Signaling in Growth, Metabolism, and Disease.

Wolfson, R.L. and Sabatini, D.M. Cell Metabolism 26:301-309 (2017). The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway.

Wolfson, R.L., et al. Nature doi:10.1038/nature21423 (2017). KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.

Chantranupong, L., et al. Cell 165:153-164 (2016). The CASTOR proteins are arginine sensors for the mTORC1 pathway.

Saxton, R.A.., et al. Science 351:53-58 (2016). Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway.

Wolfson, R.L., et al. Science 351:43-47 (2016). Sestrin2 is a leucine sensor for the mTORC1 pathway.

Wang, S., et al. Science 347:188-194 (2015). Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1.

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