mTOR: A Master Regulator of Growth and Metabolism

Navitor has deep and proprietary insights into the biological pathways that regulate mTORC1, a master regulator of cell growth and metabolism. Our novel therapeutics are designed to specifically modulate mTORC1 signaling to normalize cellular metabolic response and treat disease.

The mechanistic target of rapamycin (mTOR) pathway integrates inputs from its surroundings to regulate diverse cellular processes including proliferation, growth, survival, motility, autophagy as well as protein, lipid and nucleic acid synthesis. As a central signaling hub in many central cellular processes, previous approaches to therapeutic targeting of mTOR have not achieved sufficient specificity to enable broad therapeutic application. Navitor’s unique approach selectively targets mTORC1, one of the two distinct complexes within the mTOR pathway, which is central to the cell’s ability to sense and respond to nutrients, certain growth factors as well as energy and redox status.

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