Alan Crane

Alan joined Polaris Partners in 2002 and serves as an entrepreneur partner. In this role, he focuses on building and investing in healthcare companies.

He has served as founder, chairman, and/or CEO in building eight Polaris companies. His current and past portfolio include: Momenta Pharmaceuticals, Visterra, Navitor Pharmaceuticals, Dyno Therapeutics, Pandion Therapeutics, KSQ Therapeutics, T2 Biosystems, Ocular Therapeutix, Sirtris Pharmaceuticals, Adnexus Therapeutics, Arsia Therapeutics, Seventh Sense Biosystems, Cerulean Pharma, and XTuit Pharmaceuticals. From 2002 to 2006, Alan was president and CEO of Momenta Pharmaceuticals (NASDAQ: MNTA). He joined Momenta as the fifth employee and built it into a public company, creating an advanced and diversified pipeline, entering into two strategic collaborations with Novartis and raising $275 million. The first product from Momenta’s pipeline achieved over $1B during its first year of sales.

Prior to Polaris, Alan was senior vice president of global corporate development at Millennium Pharmaceuticals, where he was responsible for leading Millennium’s strategic partnering, mergers and acquisitions, and licensing activities, generating over $2B in partner funding and acquiring 19 development stage products. Among these products was Velcade®, which became the main basis of the company’s $9B acquisition by Takeda. Before joining Millennium, Alan was a marketing executive at DuPont-Merck and a consultant with the Boston Consulting Group and Arthur D. Little.

Alan received Ernst & Young’s Entrepreneur of the Year award for New England and is an Always-On Venture Capital 100 recipient. His current and former non-profit positions include: selection committee for the Harvard Life Lab, expert-in-residence at the Harvard School of Engineering, board member of the Boston Children’s Hospital Trust, founder and vice chair of the Autism Consortium, and president of the board of Gann Academy.

Alan earned a BA in biology, summa cum laude, from Harvard College, an MA in cellular and developmental biology from Harvard Graduate School of Arts & Sciences, and an MBA, with honors, from Harvard Business School. He also spent two years studying towards an MD at Harvard Medical School.

John Creecy

Mr. Creecy is the Chief Executive Officer and a Director of Remeditex Ventures, LLC, a biomedical investment company that seeks to build a robust biomedical portfolio through investments in early-stage university projects and start-up companies within the biomedical industry. Prior to joining Remeditex Mr. Creecy served as President and Chief Executive Officer of Hunt Petroleum Corporation, an Oil and Gas Exploration and Development Company with operations located worldwide. Before Hunt Petroleum he was the Chief Operating Officer of the Hodges Companies, Inc. a closely held private investment entity holding primarily real estate, oil and gas, and agricultural investments.

For more than 30 years Mr. Creecy has served in various board positions within the All Saints Health System in Ft. Worth, Texas now a part of the Baylor Scott and White System. He is currently Chairman of the Board of the Baylor Scott White All Saints Medical Center in Fort Worth. In addition, he has served on the university hospital boards affiliated with the UT Southwestern Medical Center in Dallas, Texas and has been a board member of the Baylor Research Institute located in Dallas, Texas. Mr. Creecy has also served on various boards of multiple early stage biomedical companies in which Remeditex Ventures has invested.

Mr. Creecy is a graduate of Texas Tech University with a Bachelor’s Degree in Accounting and holds a Master’s of Science Degree in Accounting from the University of North Texas. He is a former Certified Public Accountant and currently serves as a member of other various business and civic organizations.

Rajeev Dadoo

Rajeev joined SR One in 2004 and is an alum of the Kauffman Fellows Program. His prior and current investments include Adheron, iPierian, True North, Propeller Health, Concert Pharmaceuticals, CyDex Pharmaceuticals, NeuroTherapeutics Pharma, Tranquis Therapeutics, IlluminOss Medical, and Avhana Health. Rajeev also spent time with GSK’s competitive excellence group, where he worked on company-wide strategic projects and operational projects. Prior to SR One, Rajeev worked at Genentech, where his role included technology and clinical development, and at Bio-Rad Laboratories in a product development role. In addition, Rajeev has worked in business development at Genome Therapeutics and was a co-founder of Unimicro Technologies.

Rajeev received his BA in chemistry and mathematics from Knox College, his MBA from the Wharton School of the University of Pennsylvania, and his PhD in chemistry from Stanford University.

Thomas E. Hughes, PhD

Dr. Tom Hughes has more than 30 years of industry experience in the development and commercialization of pharmaceutical products. Prior to joining Navitor, Dr. Hughes served as President and Chief Scientific Officer of Zafgen and previously led Zafgen as CEO from 2008 to 2017. During this time, Dr. Hughes established Zafgen as a leading biotechnology company working in the area of rare and prevalent metabolic disorders and led the company through its Initial Public Offering in 2014. Prior to Zafgen, Dr. Hughes held several positions at Novartis including Global Head of the Cardiovascular and Metabolic Diseases Therapeutic Area at the Novartis Institutes for BioMedical Research in Cambridge, MA. In these roles, he oversaw many drug discovery and development projects targeting major global aging-related health issues including obesity, diabetes, and heart disease. Dr. Hughes currently serves as a member of the Board of Directors of miRagen Therapeutics, Inc., and is a member of several scientific and strategic advisory boards, including Broadview Ventures, HotSpot Therapeutics, and FaunaBio.

Dr. Hughes holds a PhD in nutritional biochemistry from Tufts University, an MS in zoology from Virginia Polytechnic Institute & State University, and a BA in biology from Franklin and Marshall College.

James Randall “Randy” Owen, MD

James Randall “Randy” Owen has nearly 20 years of biopharma industry leadership experience in neuroscience drug development. Before joining Navitor, Dr. Owen served as Senior Vice President, Clinical Development and Chief Medical Officer at Acadia Pharmaceuticals Inc, where he led the development of pimavanserin, a 5HT2a inverse agonist, for the treatment of Parkinson’s disease psychosis as well as dementia-related psychosis, depression, and schizophrenias.

Prior to Acadia, he served as Vice President, U.S. Clinical Affairs at Lundbeck LLC, where he directed the evaluation of compounds across a range of neurological and psychiatric disorders, including pediatric epilepsies, stroke, Alzheimer’s disease, and neurogenic orthostatic hypotension.

Earlier in his career, he served in positions of increasing responsibility at Abbott (now Abbvie) and Merck, where he worked on an array of neuroscience compounds, including substance P antagonism and GABA subtype selective modulators. He also served as Group Director, Global Clinical Research at Bristol-Myers Squibb Company where he co-led the life-cycle management of aripiprazole during a period of product extensions in psychiatric indications in the United States and Europe.

Dr. Owen received his BA at Haverford College, his MD at East Tennessee State University, Quillen College of Medicine, and completed his psychiatric residency at Emory University.

Eddine Saiah, PhD

Eddine Saiah has over 20 years of drug discovery, research, and development experience in biotechnology and pharmaceutical companies, and he has led the efforts in the advancement of more than ten new molecular entities into clinical development over his career. His expertise spans a broad range of drug targets for multiple diseases including diabetes, obesity, oncology, inflammation, cardiovascular, and pain. Before joining Navitor, he led the drug discovery and medicinal chemistry activities for several portfolio companies of Atlas Venture, including Raze Therapeutics and Quartet Medicine.

Previously, he served for a decade in senior R&D roles at Pfizer and Wyeth Research, which was acquired by Pfizer. Dr. Saiah was a Director of Medicinal Chemistry and Research Fellow at Pfizer, focused on R&D efforts in the inflammation, immunology, and rare disease research units. At Wyeth, he served in R&D roles of increasing responsibility and ultimately as the Head of Medicinal Chemistry for the Cambridge, MA site managing cardiovascular and metabolic disease programs as well as inflammation programs on a range of drug discovery targets including kinases, G protein-coupled receptors, proteases, nuclear hormone receptors, and protein-protein interactions.

Dr. Saiah was a postdoctoral research fellow at the Mayo Clinic’s Neuroscience Research Center. He received his PhD in chemistry from Pierre & Marie Curie University in Paris, France, and the Cancer Research Institute in Villejuif, France. Dr. Saiah is the co-author and co-inventor of more than 90 publications, scientific presentations, and patents.

Rick Lundberg

Rick Lundberg has nearly 30 years of strategic, operational, and commercial experience in the life sciences industry that ranges from de novo ventures to leading global biopharmaceutical companies. Mr. Lundberg is a member of the company’s founding team and has overall responsibility for corporate development, finance, and administration.

Prior to joining Navitor, Mr. Lundberg founded 7S BioVentures, which provided business development and corporate strategy advisory services to emerging life sciences companies. From 2006 to 2009, he was responsible for ex-U.S. commercial strategy and business development at Targanta Therapeutics. Previously, Mr. Lundberg led therapeutics business development initiatives and managed the genomics services business at Celera Genomics. He began his career at Biogen, where he served for nearly a decade in a broad range of business roles, including business development, program management, investor relations, sales, and marketing.

Mr. Lundberg holds a BA in Biochemical Sciences from Harvard University.

Jack A. Khattar

Jack A. Khattar is the founder of Supernus Pharmaceuticals and has served as President, Chief Executive Officer and Secretary, and a Director since 2005. From 1999 to 2005, he served in various positions during that time as a board member, President, and Chief Executive Officer of Shire laboratories Inc., the drug delivery subsidiary of Shire plc. Prior to that, Jack served as an executive officer and the chairman of the management committee at CIMA Labs Inc. (CIMA), a drug delivery company where he was also responsible for business development, corporate alliances, and strategic planning. Prior to joining CIMA in 1995, he held several marketing and business development positions at Merck & Co., Novartis, Playtex, and Kodak in various locations, including the United States, Europe, and the Middle East. Jack served on the board of Rockville Economic Development, Inc. from 2003 until 2013, and Prevacus, Inc. from 2015 until 2020. He currently serves on the advisory board of New Rhein Healthcare, a private equity firm, and as Chairman of the board of directors of scPharmaceuticals, a publicly traded pharmaceutical company.

Jack received a BBA from American University of Beirut and an MBA from the Wharton School of the University of Pennsylvania.

David M. Madden

Dave is Founder and Principal of Narrow River Management, LP, a company engaged in drug licensing and development. From 2011 through 2017, he was CEO of River Vision Development Corp., an entity formed and managed by Narrow River for the development of teprotumumab for thyroid eye disease and sold to Horizon Pharma in 2017. Prior to founding Narrow River, Dave was Chairman and interim CEO of Adolor Corp. until its sale to Cubist Pharmaceuticals in 2011. He was the Co-CEO of Royalty Pharma, a company engaged in buying drug royalties, from 1997-2003. Prior to that he was CEO of Selectide Corp., a combinatorial chemistry-based drug discovery company sold to Marion Merrell Dow in 1995. Dave started his career at PaineWebber Development Corp in 1987, leaving in 1992 to join Selectide as its CEO. He was Chairman of Dicerna Pharmaceuticals from 2009-2019 and served on the board of Trustees of the Hospital for Special Surgery from 2004-2016.

Dave received a BSEE in Electrical Engineering from Union College and an MBA from Columbia University.

Marian Nakada, PhD

Marian Nakada has almost 30 years of experience in the pharmaceutical industry, starting her career at the laboratory bench at Centocor and moving to a research leadership role before Centocor’s acquisition by Johnson & Johnson in 1999.

She transitioned to Janssen Business Development where she executed deals to support the expansion of the Biologics portfolio. She joined JJDC, Johnson & Johnson’s corporate venture group, in 2013 and some of her investments include Padlock Therapeutics, CoStim Pharmaceuticals, and Vedanta Biosciences. She is passionate about leveraging Johnson & Johnson’s capabilities to help her portfolio companies succeed. Marian has a B.A. in Biology from Harvard College and a Ph.D. in Pharmacology from the University of Pennsylvania. She is currently on the Boards of Navitor Pharmaceuticals, Twenty-eight Seven Therapeutics, Ribon Therapeutics, Artizan Biosciences as well as the New England Venture Capital Association where she is working to champion change as an active contributor to its Diversity & Inclusion Committee.