Board of Directors
Alan Crane
Co-founder and Chairman of the Board of Navitor, Partner and Entrepreneur, Polaris Partners

Alan Crane joined Polaris Partners in 2002 as an Entrepreneur Partner. In this role, he focuses on building and investing in healthcare companies. He has served as founder and/or has played a significant role as chairman and CEO in building seven Polaris companies including: Momenta Pharmaceuticals (NASDAQ: MNTA), Cerulean Pharma (acquired by Dare Bioscience, NASDAQ:DARE), Visterra (acquired by Otsuka), Navitor Pharmaceuticals, XTuit Pharmaceuticals, Arsia Therapeutics (acquired by Eagle Pharmaceuticals), and Pandion Therapeutics. In addition, he currently serves on the board of KSQ Therapeutics, Seventh Sense Biosystems and has previously represented Polaris on the boards of T2 Biosystems (NASDAQ: TTOO), Ocular Therapeutix (NASDAQ: OCUL), Sirtris Pharmaceuticals (NASDAQ: SIRT, acquired by Glaxo SmithKline) and Adnexus Therapeutics (Bristol Myers Squibb). From 2002 to 2006, Alan was President and CEO of Momenta Pharmaceuticals (NASDAQ: MNTA). He joined Momenta as the fifth employee and built it into a public company, creating an advanced and diversified pipeline, entering into two strategic collaborations with Novartis and raising $275 million. The first product from Momenta’s pipeline achieved over $1B during its first year of sales.

Prior to Polaris, Alan was Senior Vice President of Global Corporate Development at Millennium Pharmaceuticals, where he was responsible for leading Millennium’s strategic partnering, mergers and acquisitions, and licensing activities, generating over $2B in partner funding and acquiring 19 development stage products. Among these products was Velcade® which became the main basis of the company’s $9B acquisition by Takeda. Before joining Millennium, Alan was a marketing executive at DuPont-Merck and a consultant with the Boston Consulting Group and Arthur D. Little.

Alan received the Ernst & Young’s Entrepreneur of the Year award for New England and is an Always-On Venture Capital 100 recipient. His current and former non-profit positions include: Selection Committee for the Harvard Life Lab, Expert-in-Residence at the Harvard School of Engineering, Board Member of the Boston Children’s Hospital Trust, Founder and Vice Chair of the Autism Consortium, and President of the Board of Gann Academy.

Alan earned a BA in Biology, summa cum laude, from Harvard College, an MA in Cellular and Developmental Biology from Harvard Graduate School of Arts & Sciences and an MBA, with honors, from Harvard Business School. He also spent two years studying towards an MD at Harvard Medical School.

Alan enjoys spending his free time traveling with his wife and three sons and working with non-profits in education and healthcare.

Kevin Bitterman, PhD
Partner, Atlas Venture

Dr. Bitterman is a Partner at Atlas Venture.  He serves on the boards of Navitor and Akero Therapeutics (NASDAQ: AKRO) and is a co-founder and board member of Disc Therapeutics. He was the founding CEO of Editas Medicine (NASDAQ: EDIT), Morphic Therapeutic (NASDAQ: MORF) and Visterra (acquired by Otsuka), and co-founded Genocea Biosciences (NASDAQ: GNCA). He previously served as a director of Kala Pharmaceuticals (NASDAQ: KALA), Neuronetics (NASDAQ: STIM), Taris Biomedical (acquired by Allergan) and Vets First Choice (NASDAQ: CVET) among other ventures. Prior to joining Atlas Venture in 2017, Kevin was a partner at Polaris Partners, where he had been a member of the healthcare team since 2004.

Kevin is active in the local life science and healthcare start-up community, serving on the Scientific Advisory Board of the Massachusetts Life Sciences Center (MLSC) and as Board Chair of the New England Venture Capital Association (NEVCA).  He received a BA in biology, summa cum laude, from Rutgers University before completing his PhD in genetics at Harvard Medical School.  He has published numerous scientific articles and is an inventor on several issued patents.

John Creecy
Chief Executive Officer and a Director of Remeditex Venture

Mr. Creecy is Chief Executive Officer and a Director of Remeditex Ventures after serving as President and Chief Executive Officer of Hunt Petroleum Corporation. Prior to that, Mr. Creecy served as Chief Operating Officer of Hodges Company, Inc. Mr. Creecy is a Graduate of Texas Tech University with a Bachelor’s Degree in Accounting and holds a Master of Science Degree in Tax from North Texas State University (now the University of North Texas). Mr. Creecy is a member of both the Dallas Assembly and the Dallas Citizens Council, civic organizations comprised of business leaders in Dallas.

Rajeev Dadoo
Partner, SR One

Rajeev joined SR One in 2004 and is an alum of the Kauffman Fellows Program. He has previously worked in the Competitive Excellence group within GSK on company-wide strategic and operational projects. Rajeev has also worked at Genentech, where his role included technology and clinical development, and at Bio-Rad Laboratories in a product development role. In addition, he worked at Genome Therapeutics in business development and was a co-founder of Unimicro Technologies.

Rajeev is currently also on the Boards of Avhana, Illuminoss and Tranquis and previously served on the Boards of Adheron (acquired by Roche), Concert (NASDAQ:CNCE), Cydex (acquired by Ligand), iPierian (acquired by BMS), NeuroTherapeutics Pharma, Propeller (acquired by ResMed) and True North (acquired by Bioverativ).

Rajeev has an MBA from The Wharton School of Business at the University of Pennsylvania, a Ph.D. in Chemistry from Stanford University and a B.A. in Math and Chemistry from Knox College.

Thomas E. Hughes, PhD
Chief Executive Officer of Navitor

Tom Hughes has more than 30 years of industry experience in the development and commercialization of pharmaceutical products. Prior to joining Navitor, Dr. Hughes served as President and Chief Scientific Officer of Zafgen and previously led Zafgen as CEO from 2008 to 2017. During this time, Dr. Hughes established Zafgen as a leading biotechnology company working in the area of rare and prevalent metabolic disorders and led the company through its Initial Public Offering in 2014. Prior to Zafgen, Dr. Hughes held several positions at Novartis including Global Head of the Cardiovascular and Metabolic Diseases Therapeutic Area at the Novartis Institutes for BioMedical Research in Cambridge, MA. In these roles, he oversaw many drug discovery and development projects targeting major global aging-related health issues including obesity, diabetes, and heart disease. Dr. Hughes currently serves as a member of the Board of Directors of miRagen Therapeutics, Inc., is an advisor to Atlas Venture, and is a member of several scientific and strategic advisory boards, including Broadview Ventures, HotSpot Therapeutics, and Nimbus Therapeutics.

Dr. Hughes holds a Ph.D. in nutritional biochemistry from Tufts University, an M.S. in zoology from Virginia Polytechnic Institute & State University and a B.A. in biology from Franklin and Marshall College

David M. Madden
Independent Director, Founder and Principal, Narrow River Management, LP

David Madden is a pharmaceutical industry veteran. He is founder and principal with Narrow River Management, LP, an investment management company with a focus on equity investment in, and management of, drug development projects. Since 2009, he has served as chairman of the board of directors of Dicerna Pharmaceuticals.

From 2000 to 2003, Mr. Madden was co-CEO of Royalty Pharma AG, a private investment management firm specializing in the acquisition of royalty interests in pharmaceutical products. Prior to that position, he was a managing member of Pharmaceutical Partners, LLC, and was president, CEO and a director of Selectide Corporation, a development-stage pharmaceutical company, which was acquired by Marion Merrill Dow in 1995. Additionally, Mr. Madden served as chairman of the board of Adolor Corporation, and is a member of the board of directors of the Hospital for Special Surgery in New York City.

Mr. Madden holds a B.S. in electrical engineering from Union College and an M.B.A. from Columbia University.

Marian Nakada, PhD
Vice President, Venture Investments, Johnson & Johnson Innovation–JJDC, Inc.

Marian is Vice President, Venture Investments at Johnson & Johnson Innovation—JJDC Inc., the corporate venture arm of Johnson & Johnson and is based in Boston. Marian previously held roles at Centocor R&D, Janssen R&D, and Janssen Business Development. She has a BA in Biology from Harvard College and a PhD in Pharmacology from the University of Pennsylvania. Marian was the JJDC investor for CoStim Pharmaceuticals (acquired by Novartis), Rodin Therapeutics, and Padlock Therapeutics (acquired by BMS) and currently also sits on the Boards of PhaseBio Pharmaceuticals, Accelerator Life Science Partners, and the New England Venture Capital Association.

Vinzenz Ploerer
President & CEO, Brace Pharma Capital, LLC

Vinzenz Ploerer is Brace Pharma Capital’s President and CEO, and sits on the Board of Directors. Vinzenz has worked as a life science executive for over 20 years, and brings extensive leadership experience in operations, acquisitions and business development. Prior to launching Brace in 2013, he worked at EMS S/A as Senior Vice President of Strategy and Operations. He has also held multiple senior leadership positions at Novartis/Sandoz including various country head roles. Vinzenz currently sits on several corporate boards including GeNO, Therabron, Tyrogenex and Navitor. Vinzenz obtained his Masters of Business Administration from the University of Innsbruck.

George Vlasuk, PhD
President and Chief Scientific Officer of Navitor

George Vlasuk is a scientifically trained executive with nearly 30 years of leadership experience in drug discovery and development at small and large biotechnology and pharmaceutical companies. Before joining Navitor, Dr. Vlasuk served as Chief Executive Officer of Sirtris, a GlaxoSmithKline Company, from 2009 to 2013. Prior to Sirtris, Dr. Vlasuk was the Vice President, Metabolic Disease and Hemophilia Research, at Wyeth Pharmaceuticals. Earlier at Wyeth, Dr. Vlasuk led the areas of cardiovascular and metabolic diseases (CVMD), focusing on Type 2 diabetes, obesity, diabetic complications, heart failure, dyslipidemia/ atherosclerosis and cardiac arrhythmia.

Prior to Wyeth, Dr. Vlasuk served as Chief Scientific Officer and Executive Vice President of Research and Development at the biopharmaceutical company Corvas International, from 1991 until 2003, following the merger of Corvas and Dendreon Corporation. While at Corvas, he directed research in the discovery, pre-clinical and clinical evaluations of novel anti-thrombotic, anti-inflammatory and anti-tumor agents. As a member of the senior management team and the board of directors at Corvas, Dr. Vlasuk represented Corvas in discussions with potential corporate partners, public and private investors and equity analysts.

Earlier in his career, Dr. Vlasuk led a research team at Merck and Co., and was responsible for multiple discovery programs in the field of cardiovascular medicine. Prior to Merck, Dr. Vlasuk was a researcher in small proteins and peptide compounds at California Biotechnology Inc. (now Scios, part of Johnson & Johnson), where he joined as one of the first 20 employees before the initial public offering. Dr. Vlasuk received his undergraduate degree in Clinical Chemistry from The University of South Florida and his PhD in Chemistry/Biochemistry from Kent State University. He received postdoctoral training in molecular biology at The State University of New York at Stony Brook, where he received a three-year fellowship from the National Institutes of Health. Dr. Vlasuk is the author of more than 100 peer-reviewed scientific publications, book chapters and reviews and 38 issued U.S. and foreign patents.

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